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Is also an antigenic target in APS. Abs to PF4 are implicated in heparin-induced thrombocytopenia but have also been detected in patients with APS without a history of heparin-induced thrombocytopenia or recent exposure to heparin. Levels of anti-PF4 Abs also correlate with levels of IgM aPL and IgM anti-2GPI Abs, but have activity independent of both [55,56]. These data suggest another potentiall
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Ished betweenand .We chose to limit the data of publication toIshed betweenand .We chose to limit the in
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Ted with ATA, anti-U1RNP, lymphopenia, and IFN/IFN receptor 2 (IFNAR2) missense mutation rs7279064 GG or GT (114). Other variants in the IFN pathway have also been well established in SSc. Polymorphismsin IRF5, IRF7, and IRF8 have been identified. IRF5 mediates IFN activity and is an important inflammatory signaling pathway. Polymorphisms in IRF5 are associated with SLE, RA, ulcerative colitis, an
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The prioritization of health interventions [22]. The trade-offs between efficiency and equity are among these criteria, and have long been emphasized in the field of HIV/AIDS treatment and prevention [23,24]. Several mathematical frameworks, including mathematical programming, have been proposed to incorporate equity considerations into resource allocation in the public sector [25-29]. Several of
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D if the HSV-2 diagnosis occurred at or after HIV seroconversion, and ulcers were excluded if they occurred at or after HIV seroconversion. We estimated the proportion of participants with 1 ulcer AE classified as Gradeor above (i.e., moderate, severe, or potentially life-threatening), 1 STI examination during which a perianal ulcer was detected, and 1 STI examination during which a groin ulcer
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