City to activate complement [101]. The frequency of deficient or non-functional MASP-2 ranges from 2 to 19 in different populations with the highest values in Africans [102]. We speculate that relative MBL excess in the setting of relatively low C4 levels or deficient MASP-2 may lead to MBL-mediated enhanced viral infections in clinical settings. Thus, we propose that MBL, C4 and MASP-2, among o

Infections using high level rhMBL (10 mg/ml) in 5 serum (i.e. diluted 20-fold). However, such a high concentration of rhMBL is considered supraphysiological if adjusted for the 20-fold dilution factor of serum. Although human MBL is produced primarily in the liver, extrahepatic MBL synthesis has been found in the gastrointestinal tract, middle ear fluid, and nasopharyngeal secretions. It is possi

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Ic? Findings from a population based study in Karachi, Pakistan. BMC Infect. Dis., 9, 38. http://dx.doi.org/10.1186/1471-2334-9-38 Fox, M. P., Mazimba, A., Seidenberg, P., Crooks, D., Sikateyo, B., Rosen, S. (2010). Barriers to initiation of antiretroviral treatment in rural and urban areas of Zambia: a cross-sectional study of cost, stigma, and perceptions about ART. J. Int. AIDS Soc., 13, 8. h

Es obtained with the LTR-specific primers represent a sum of transcripts originating from the host promoter and of viral transcripts, which also contain LTR sequence at their 3' ends. Therefore, the measured ratio corresponds to the equation a+b/b, where `a' is the number of host-viral chimeric transcripts and `b' the number of viral transcripts (see Supplemental text 2). First, we determined this

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