Ted with ATA, anti-U1RNP, lymphopenia, and IFN/IFN receptor 2 (IFNAR2) missense mutation rs7279064 GG or GT (114). Other variants in the IFN pathway have also been well established in SSc. Polymorphismsin IRF5, IRF7, and IRF8 have been identified. IRF5 mediates IFN activity and is an important inflammatory signaling pathway. Polymorphisms in IRF5 are associated with SLE, RA, ulcerative colitis, an